Bishop travel to Ryhope on Tuesday night.
The last encounter for these two teams was back in September when they drew 1-1.
Ryhope sit 4th in the table after beating Redcar 2-0 at the weekend.
Bishop were beaten by top of the league, Consett 2-1, taking them down to 19th place.
The last five games for these two has seen Ryhope pick up nine points and Bishop have only got the singular point from their draw with Billingham.
With only six games left for Bishop they desperately need to pick up some points to get themselves out of the relegation hot seat.
Bishop are only three points in front of Billingham.
Both Penrith and Northallerton won their games at the weekend, securing them three vital points and taking them above Bishop by two points.
The bottom four are in a dog fight and at the moment Bishop and Billingham are losing.
There are some very tough games ahead for the two blues and they need to fight with everything they have to get points and get themselves safe to stay in Division One.
Penrith also have a midweek game on Wednesday against Whickham.